Human tumor necrosis factor tr21 and methods based thereon
AssigneeHuman Genome Sciences, Inc.
InventorsSteven M. Ruben, David Hilbert
Life of this patent
Estimating the term…
Abstract
The present invention relates to TR21 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human TR21 protein. TR21 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR21 activity.
Claims20
An isolated polypeptide comprising an amino acid sequence at least 90% identical to a sequence selected from the group consisting of:
- (a) amino acids from 2 to 81 in SEQ ID NO:2 (FIG. 1);
- (b) amino acids from 2 to 38 in SEQ ID NO:2 (FIG. 1);
- (c) amino acids from 2 to 46 in SEQ ID NO:2 (FIG. 1);
- (d) amino acids from 2 to 62 in SEQ ID NO:2 (FIG. 1);
- and
- optionally, a heterologous polypeptide sequence
An isolated antibody that binds specifically to a polypeptide consisting of amino acid residues selected from the group consisting of:
- (a) amino acids 2 to 81 in SEQ ID NO:2;
- (b) amino acids 2 to 38 in SEQ ID NO:2;
- (c) amino acids 2 to 46 in SEQ ID NO:2;
- (d) amino acids 2 to 62 in SEQ ID NO:2;
- (e) amino acids 3 to 15 in SEQ ID NO:2;
- (f) amino acids 39 to 45 in SEQ ID NO:2;
- (g) amino acids 51 to 53 in SEQ ID NO:2;
- (h) amino acids 59 to 61 in SEQ ID NO:2;
- (i) amino acids 104 to 112 in SEQ ID NO:2;
- (j) amino acids 115 to 122 in SEQ ID NO:2;
- (k) amino acids 136 to 138 in SEQ ID NO:2;
- (l) amino acids 147 to 153 in SEQ ID NO:2;
- and
- (m) amino acids 178 to 182 in SEQ ID NO:2.
A method of killing a cell that expresses TR21 polypeptide on its cell surface, comprising contacting said cell with an antibody or portion thereof that specifically binds a polypeptide consisting of amino acid residues 1-184 of SEQ ID NO:2;
- wherein said antibody or portion thereof is conjugated to a toxin.
Dependencies are inferred from the claim text.