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AssigneeBoehringer Ingelheim International GmbH
InventorsJohn E. PARK, Cornelia DORNER-CIOSSEK, Stefan HOERER, Lothar KUSSMAUL, Martin LENTER, Katharina ZIMMERMANN, Gerald BESTE, Toon LAEREMANS, Pascal MERCHIERS, Jo VERCAMMEN
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The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.
A polypeptide comprising a first immunoglobulin single variable domain specifically binding to a first epitope of A-beta and a second immunoglobulin single variable domain specifically binding to a second epitope of A-beta, wherein said first and said second epitopes of A-beta are not identical epitopes.
A polypeptide comprising an immunoglobulin single variable domain essentially consisting of four framework regions (FR1 to FR4, respectively) and three complementary determining regions (CDR1 to CDR3, respectively), wherein said CDR sequences are defined as follows:
A polypeptide comprising a VHH domain having an amino acid sequence selected from the group consisting of SEQ ID NOs:
A polypeptide comprising a first immunoglobulin single variable domain and a second immunoglobulin single variable domain, wherein the CDR sequences of said first immunoglobulin variable domain (CDR(1) sequences) and the CDR sequences of said second immunoglobulin variable domain (CDR(2) sequences) are defined as follows:
A polypeptide comprising a first immunoglobulin single variable domain and a second immunoglobulin single variable domain, wherein said first immunoglobulin single variable domain is VHH domain ABII035 (SEQ ID NO:44), and said second immunoglobulin single variable domain is VHH domain ABII059 (SEQ ID NO:45), or wherein said first immunoglobulin single variable domain is VHH domain ABII059 (SEQ ID NO:45), and said second immunoglobulin single variable domain is VHH domain ABII035 (SEQ ID NO:44).
A polypeptide selected from the group consisting of polypeptides having any of SEQ ID NOs:
Dependencies are inferred from the claim text.