ERBB2 antibodies comprising modular recognition domains
AssigneeThe Scripps Research Institute
InventorCarlos F. Barbas, III
Life of this patent
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Abstract
Antibodies containing one or more modular recognition domains (MRDs) that can be used to target the antibodies to specific sites are described. The use of antibodies containing one or more modular recognition domains to treat disease, and methods of making antibodies containing one or more modular recognition domains are also described.
Claims51
A complex comprising an antibody and at least one modular recognition domain (MRD), wherein the antibody binds to ErbB2.
A polynucleotide encoding (a) a polypeptide fusion comprising an antibody heavy chain and an MRD, (b) a polypeptide fusion comprising an antibody light chain and an MRD, or (c) a polypeptide fusion comprising an antibody heavy chain and an MRD and a polypeptide fusion comprising an antibody light chain and an MRD, wherein an antibody comprising the antibody chain binds to ErbB2.
Dependencies are inferred from the claim text.