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AssigneesVanderbilt University, University of South Florida
InventorsEdwin Weeber, Lisa Zhao, Melinda Peters
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Disclosed are methods of influencing, and enhancing, cognitive function by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is improved, in a subject in need thereof, by administering a therapeutically effective amount of Reelin, a Reelin-specific modulator or an agonist of a lipoprotein receptor to the subject. The lipoprotein receptor can be selected from candidates such as ApoER2 and VLDLR. As disclosed herein, agonists of the lipoprotein receptor for use with the inventive method include APC, Sep and Fc-RAP. In addition to administering exogenous Reelin, a Reelin-specific modulator, such as a recombinant Reelin fragment, can be used to increase Reelin levels and/or signaling.
A method of improving cognitive function in a subject, comprising the step of administering a therapeutically effective amount of Reelin, a Reelin-specific modulator or an agonist of a lipoprotein receptor to the subject.
A method of treating a symptom of a disease or disorder of the nervous system, comprising the step of administering a therapeutically effective amount of Reelin or an agonist of a lipoprotein receptor to a subject in need thereof.
A method of increasing dendritic spine density in a subject, comprising the step of administering a therapeutically effective amount of Reelin or an agonist of a lipoprotein receptor to the subject.
Dependencies are inferred from the claim text.