Novel cancer-associated antigen
AssigneeViventia Biotechnologies Inc.
InventorsFRANCINA C. CHAHAL, GLEN MACDONALD, JEANNICK CIZEAU
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Abstract
The present invention provides a novel cancer-associated antigen that can be used in the treatment and diagnosis of cancer. Further, the invention provides amino acid and nucleic acid sequence of the novel antigen, binding proteins, and immunoconjugates. The invention also relates to diagnostic and therapeutic methods and kits.
Claims26
1-31. (canceled)
An isolated protein comprising a cancer-associated variant of Mammalian Scratch, wherein the cancer-associated variant of Mammalian Scratch is expressed on the surface of cancer cells.
A method of detecting cancer cells or monitoring cancer in a subject having or suspected of having cancer comprising:
- (a) providing a sample from the subject;
- (b) extracting nucleic acid molecules encoding wild type scratch or the cancer-associated variant of scratch from the sample;
- (c) digesting the nucleic acid molecules with a KpnI restriction enzyme;
- and
- (d) determining the size of the digested nucleic acid molecules wherein the presence of undigested nucleic acid molecules indicates that the subject has a predisposition to develop cancer.
A method for treating or preventing cancer in a subject comprising preventing or decreasing the function of the cancer-associated variant of Mammalian Scratch.
Dependencies are inferred from the claim text.