Diagnostic and therapeutic treatments related to mitochondrial disorders
AssigneeThe Regents of the University of Colorado
InventorsMartha Karen Newell Rogers, Elizabeth Villalobos-Menuey, Robert Melamede, Robert E. Camley
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Abstract
The invention is based in part on the discovery that chromosomal disorders such as Down Syndrome can be diagnosed by assessing maternal mitochondrial status. Thus the invention relates to diagnostic and therapeutic methods and related products for chromosomal disorders such as Downs Syndrome, for example, for identifying a risk of fetal Downs Syndrome and methods of mitigating that risk. The methods also are useful for other therapies where it is desirable to manipulate mitochondria such as tissue generation.
Claims11
1-15. (canceled)
A modified stem cell, comprising a stem cell having a heterologous mitochondria.
A method for promoting tissue generation, comprising subjecting the modified stem cell of claim 14 to growth promoting conditions.
22-36. (canceled)
A method of generating neural tissue comprising implanting a neural stem cell of claim 32 into a subject, inducing expression of the UCP2 gene to grow neural tissue, and inducing expression of the UCP4 gene to differentiate the neural stem cells into neural tissue.
A modified oocyte or embryonic cell, comprising:
- an oocyte or embryonic cell having a microinjected heterologous mitochondria.
(canceled)
Dependencies are inferred from the claim text.