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US 2012/0058086 A1Published application
Compositions, kits, and methods for promoting ischemic and diabetic wound healing
OwnerOmaida C. Velazquez, Zhao-Jun Liuinventors
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OwnerOmaida C. Velazquez, Zhao-Jun Liuinventors
Estimating the term…
Compositions, kits and methods for promoting diabetic wound healing are based on the discovery that SDF-1α specifically upregulates expression of E-selectin in mature endothelial cells (EC), leading to an increase in EC-endothelial progenitor cell (EPC) adhesion and EPC homing. Methods for promoting healing of a wound in a diabetic subject include providing a therapeutically effective amount of a composition including E-selectin protein or a nucleic acid encoding E-selectin protein, and optionally, an agent that specifically upregulates E-selectin expression (e.g., SDF-1α). The methods can also include administering hyperbaric oxygen treatment to the subject. Administering the composition to the subject results in migration of bone marrow-derived progenitor cells to the wound, accelerated wound healing, and upregulation of E-selectin expression in the subject.
A method of promoting healing of a diabetic wound in a diabetic subject, the method comprising the steps of:
A method of upregulating E-selectin expression in a diabetic subject having a diabetic wound, the method comprising administering to the diabetic subject a composition comprising at least one rAAV virion comprising a polynucleotide encoding E-selectin, the polynucleotide interposed between a first AAV inverted terminal repeat and second AAV inverted terminal repeat, the composition in an amount effective to upregulate E-selectin expression, induce migration of bone marrow-derived progenitor cells to the wound, and accelerate healing of the wound in the subject
A method of promoting healing of a diabetic wound in a diabetic subject, the method comprising the steps of:
A kit for treating at least one diabetic wound in a mammalian subject, the kit comprising:
Dependencies are inferred from the claim text.