Anti-human ror1 antibodies
AssigneeThe U.S.A., as represented by the Secretary, Department of Health and Human Services
InventorsChristoph Rader, Sivasubramanian Baskar
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Abstract
The invention relates to antibodies having specificity for human ROR1, compositions thereof, and methods for using such antibodies, including in the diagnosis and treatment of disorders associated with aberrant ROR1 expression.
Claims47
An isolated antibody having specificity for the extracellular domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1), wherein the antibody comprises:
- (a) a heavy chain variable domain having at least 90% sequence identity to SEQ ID NO:
- 1;
- or
- (b) a light chain variable domain having at least 90% sequence identity to SEQ ID NO:
- 2;
- or
- (c) both a heavy chain of (a) and a light chain of (b).
An isolated antibody having specificity for the extracellular domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1), comprising at least one CDR having a sequence selected from the group consisting of SEQ ID NO:
- 4, SEQ ID NO:
- 6, SEQ ID NO:
- 8, SEQ ID NO:
- 11, SEQ ID NO:
- 13, and SEQ ID NO:
- 15.
Dependencies are inferred from the claim text.