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US 2012/0027727 A1Published application
Targeted nanoparticles for cancer and other disorders
AssigneeEpeius Biotechnologies Corporation
InventorsFREDERICK L. HALL, ERLINDA M. GORDON
Life of this patent
Estimating the term…
Abstract
Targeted gene therapeutic systems are provided for the treatment of cancer, including viral particles. The viral particles are engineered to specifically deliver therapeutic or diagnostic agents to a disease site, such as cancer metastatic sites. Localized dosing regimens are provided to treat diseases such as cancer.
Claims29
-56. (canceled)
A method of treating hepatic cancer in a subject in need thereof with a targeted therapeutic retroviral particle, the method comprising:
- a) systemically administering a first therapeutic course of at least 1×1011 cfu cumulative dose of a targeted therapeutic retroviral particle for at least three days;
- b) administering via hepatic-arterial infusion a second therapeutic course of at least 1×1011 cfu cumulative dose of a targeted therapeutic retroviral particle to the subject for at least three days;
- c) monitoring the subject for improvement of cancer symptoms.
-85. (canceled)
88-91. (canceled)
93-99. (canceled)
Dependencies are inferred from the claim text.