Anti-bacterial compositions and methods including targeting virulence factors of staphylococcus aureus

A compound of the formula

• wherein:
• Y is selected from the group consisting of:
• —P(O)(O−M1)(O−M2), —P(O)(OH)2, —P(O)(OH)(O−M3), —SO3H, —SO3−M4, —C(O)O−M5 and —COOH;
• X is selected from the group consisting of:
• —C(O)—, —S(O2)—, —P(O)(O−M6)-, and —CH2—;
• T is selected from the group consisting of:
• —O—, —CH2—, and —NR3—;
• A is a bridging diradical selected from the group consisting of:
• —(CH2)n—, —(C6H4)n—, —(CF2)n—, —(CCl2)n—, —(CBr2)n—, alkylene, substituted alkylene, arylene, substituted arylene, alkylenearylene, substituted alkylenearylene, arylenealkylene, substituted arylenealkylene, alkylenearylenealkylene, substituted alkylenearylenealkylene, oxyalkylene, substituted oxyalkylene, oxyalkylenearylene, substituted oxyalkylenearylene, oxyarylene, substituted oxyarylene, oxyarylenealkylene, and substituted oxyarylenealkylene;
• n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10;
• M1, M2, M3, M4, M5, M6, M7 are each independently a pharmaceutically acceptable cation;
• R3 is selected from the group consisting of:
• —H, —OH, —O−M7, aryl, substituted aryl, alkyl, substituted alkyl, —COOH, —COO−, —CO—NH2, —(CH2)n—O—CO—, and halo;
• R4 and R5 are each independently selected from the group consisting of —H, —OH, —O−M7, aryl, substituted aryl, alkyl, substituted alkyl, —COOH, —COO−, —CO—NH2, —(CH2)n—COOH, —(CH2)n—COO−, and halo;
• R1, R2, R6, R7, R8 are each independently selected from the group consisting of:
• aryl, substituted aryl, alkyl, substituted alkyl, —COOH, —COO−, —CO—NH2, —(CH2)n—O—CO—, halo, and the following substituents: