Modified chaperonin 10
AssigneeCBio Limited
InventorsDEAN JASON NAYLOR, BARBARA JANE JOHNSON, CAROLINE AMANDA DOBBIN, CHRISTOPHER BRUCE HOWARD, LINDA ALLISON WARD
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Abstract
The present invention relates to isolated Chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.
Claims33
An isolated Cpn10 polypeptide possessing immunomodulatory activity but lacking, or substantially lacking, protein folding activity.
-4. (canceled)
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An isolated Cpn10 polypeptide having immunomodulatory activity, said polypeptide comprising one or more amino acid substitutions, deletions and/or additions in the roof β-hairpin region compared to a corresponding wild-type Cpn10 polypeptide.
-14. (canceled)
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An isolated Cpn10 polypeptide having immunomodulatory activity, said polypeptide comprising one or more amino acid substitutions, deletions and/or additions in the mobile loop region and the roof β-hairpin region compared to a corresponding wild-type Cpn10 polypeptide.
-24. (canceled)
An isolated Cpn10 polypeptide, wherein the N terminus of said polypeptide is substantially replaced with a bacterial Cpn10 N terminus, wherein said polypeptide comprises the amino acid as set forth in SEQ ID NO:14.
-34. (canceled)
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Dependencies are inferred from the claim text.