Regulators of the Interferon-Alpha Receptor 1 (IFNAR1) Chain of the Interferon Receptor
OwnerSerge Fuchs, J. Alan Diehlinventors
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Abstract
The present invention includes compositions and methods for modulating a regulator of IFNAR1. The invention includes inhibitors and activators of PERK, PTP1B, and/or PKD2 wherein inhibition, or activation, of at least one of PERK, PTP1B, and PKD2 modulates the stability of IFNAR1.
Claims46
A method of modulating the stability of IFNAR1 in a cell, wherein said method comprises contacting said cell with an effective amount of a composition comprising an inhibitor of a regulator of IFNAR1.
A method of treating a disease or disorder associated with a dysfunctional IFN response in a subject in need thereof, wherein said method comprises administering to said subjcctin need thereof, a therapeutically effective amount of a composition comprising an inhibitor of a regulator of IFNAR1.
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(canceled)
A method of increasing the efficacy of endogenous IFN in a mammal in need thereof, wherein said method comprises administering to said mammal a therapeutically effective amount of a composition comprising an inhibitor of a regulator of IFNR1.
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A method of increasing the efficacy of IFN-based drug treatment in a mammal in need thereof, wherein said method coniprises administering to said mammal a therapeutically effective amount of a composition comprising an inhibitor of a regulator of IFNR1.
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A method of modulating the stability of IFNAR1 in a cell, wherein said method comprises contacting said cell with an effective amount of a composition comprising an activator of a regulator of IFNAR1.
A method of treating a disease or disorder associated with a dysfunctional IFN response in a subject in need thereof, wherein said method comprises administering to said subject a therapeutically effective amount of a composition comprising an activator of a regulator of IFNAR1.
(canceled)
(canceled)
Dependencies are inferred from the claim text.