LPA Receptor Agonists and Antagonists
AssigneeRxBio, Inc.
InventorVeeresh Gududuru
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Abstract
Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.
Claims4
A composition comprising a compound of formula (I)
- wherein,
- X1 is R1—Y1-A-;
- X2 is —Z1—P(S)(OH)2;
- X3 is hydrogen;
- A is a direct link or (CH2)l with l being an integer from 1-30;
- Y1 is (CH2)l with l being an integer from 1-30;
- Z1 is oxygen;
- Q1 and Q2 are independently selected from the group consisting of H, ═NR4, ═O, or —NR5R6;
- R1 is independently a straight or branched-chain C1 to C30 alkyl substituted with or more cycloalkyl or a straight or branched-chain C2 to C30 alkenyl substituted with one or more cycloalkyl;
- and
- R2, R3, R4, R5, R6, R7, and R8 are independently hydrogen, a straight or branched-chain C1 to C30 alkyl, or a straight or branched-chain C2 to C30 alkenyl.
A composition comprising a compound of formula (I)
- wherein,
- X1 is R1—Y1-A-;
- X2 is (HO)(BH3)PO—Z1—;
- X3 is hydrogen;
- A is a direct link or (CH2)l with l being an integer from 1-30;
- Y1 is (CH2)l with l being an integer from 1-30;
- Z1 is oxygen;
- Q1 and Q2 are independently selected from the group consisting of H, ═NR4, ═O, or —NR5R6;
- R1 is independently a straight or branched-chain C1 to C30 alkyl optionally substituted with cycloalkyl or a straight or branched-chain C2 to C30 alkenyl optionally substituted with cycloalkyl;
- and
- R2, R3, R4, R5, R6, R7, and R8 are independently hydrogen, a straight or branched-chain C1 to C30 alkyl, or a straight or branched-chain C2 to C30 alkenyl.
Dependencies are inferred from the claim text.