Essential genes encoding conserved metabolic pathway function in autotrophic solventogenic clostridial species
AssigneeCoskata, Inc.
InventorsAndrew Reeves, Fenglin Yin
Life of this patent
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Abstract
Essential genes coding for the metabolic pathway of solventogenic autotrophic Clostridia were sequenced, and functionality was confirmed. The present invention utilizes a comparative inter-species approach to develop the minimum set of essential genes for metabolic function and estimate productivity in species of suspected solventogenic capability.
Claims8
An isolated and purified polynucleotide encoding a polypeptide sequence with a P value of 1×10−20 or smaller when compared to SEQ ID NO. 1.
An isolated and purified polynucleotide encoding a polypeptide sequence with a P value of 1×10−20 or smaller when compared to the sequence of SEQ ID NO. 2.
An isolated and purified polynucleotide encoding a polypeptide sequence with a P value of 1×10−20 or smaller when compared to the sequence of SEQ ID NO. 3.
A method of confirming high titer autotrophic solventogenesis function of a potentially commercially viable microorganism, said method comprising:
- sequencing the genome of said potentially commercially viable microorganism;
- comparing a resulting sequence of the genome of the microorganism to SEQ ID NO. 1.
Dependencies are inferred from the claim text.