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AssigneesBioleaders Corporation, Kookmin University Industry Academy Cooperation Foundation
InventorsMoon-Hee Sung, Haryoung Poo, Il Han Lee
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A surface expression vector for preparing HPV vaccines, in which the surface expression vector contains a gene encoding a repE mutant protein having an amino acid sequence of SEQ ID NO: 1, a promoter, a poly-gamma-glutamate synthetase complex gene, and a gene which is linked with the poly-gamma-glutamate synthetase complex gene and encodes a tumor induction-associated antigen protein of human papillomavirus. An expression vector constitutively expressing a high level of the human papillomavirus (HPV) antigen protein is provided. Also, a recombinant lactic acid bacteria, transformed with the expression vector and expressing the HPV antigen protein on the surface thereof, and a composition comprising the recombinant lactic acid bacteria are provided. The recombinant lactic acid bacteria and the composition are very effective as a vaccine for the treatment of cervical cancer, because they can be applied orally or directly to the vagina.
A surface expression vector for preparing human papillomavirus (HPV) vaccines, the surface expression vector comprising a gene encoding a repE mutant protein having an amino acid sequence of SEQ ID NO:
A surface expression vector for preparing HPV vaccines, the surface expression vector comprising a gene encoding a repE mutant protein having an amino acid sequence of SEQ ID NO:
A surface expression vector for preparing HPV vaccines, the surface expression vector comprising a gene encoding a repE mutant protein having an amino acid sequence of SEQ ID NO:
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