Antibody having a t-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
AssigneeTechnion Research & Development
InventorsYoram REITER, Galit Denkberg
Life of this patent
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Abstract
An isolated molecule which comprises an antibody specifically bindable with a binding affinity below 20 nanomolar, preferably below 10 nanomolar, to a human major histocompatibility complex (MHC) class I being complexed with a HLA-restricted antigen and optionally further comprises an identifiable or therapeutic moiety conjugated to the antibody.
Claims14
An isolated soluble antibody specifically bindable with a binding affinity below 20 nanomolar to a human major histocompatibility complex (MHC) class I protein complexed with a HLA-restricted antigen, wherein said soluble antibody binds viral infected cells or tumor cells naturally presenting said human MHC class I complexed with said HLA-restricted antigen.
Dependencies are inferred from the claim text.