Bi-layered bone-like scaffolds
AssigneeBoard of Regents, The University of Texas System
InventorsDaniel Sunho Oh, Anson Ong
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Abstract
Disclosed are biomedical scaffolds that may be used, for example, for treatment of bone diseases and bone repair. Methods of preparing such scaffolds are also disclosed. These scaffolds permit nutrient and ion flow such that bone regeneration in the area surrounding the scaffold is promoted. Also disclosed are kits that include the scaffolds set forth herein.
Claims39
A biomedical scaffold, comprising:
- a) a core component comprising:
- (i) an open pore structure of micropores that are interconnected;
- and
- (ii) a hollowed strut comprising secondary microchannels that are interconnected;
- and
- b) a cortical layer in contact with at least a portion of a surface of the core component.
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The scaffold of claim 7, wherein the average diameter of the microchannels of the cortical layer is about 1 μm to about 2000 μm.
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A method of making a bone scaffold, comprising:
- a) contacting a core polymer sponge with a composition comprising a calcium phosphate, wherein at least a portion of the sponge becomes coated with the composition;
- and
- b) drying the composition-coated sponge, wherein a bone scaffold is formed.
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Dependencies are inferred from the claim text.