Recombinant Monovalent Antibodies
AssigneesInstitut National De La Sante Ed De La Recherche Medicale (Inserm), Effimune
InventorsBernard Vanhove, Caroline Mary, Flora Coulon
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Abstract
The invention relates to recombinant monovalent antibodies which are heterodimers of a first protein chain comprising the variable domain of the heavy chain of an antibody of interest and the CH2 and CH3 domains of an IgG immunoglobulin and a second protein chain comprising the variable domain of the light chain of said immunoglobulin of interest and the CH2 and CH3 domains of said IgG immunoglobulin. These antibodies can be used in particular as therapeutic agents in all cases where monovalent binding to a ligand such a cellular receptor is required.
Claims13
A recombinant antibody derived from a parent antibody directed against an antigen of interest, wherein said recombinant antibody is an heterodimer of:
- a first protein chain consisting essentially of, from its N-terminus to its C-terminus:
- a region A having the structure of the variable domain of the heavy chain of an immunoglobulin, said region A comprising the CDRs of the heavy chain of said parent antibody;
- a region B consisting of a peptide linker and the CH2 and CH3 domains of an IgG immunoglobulin;
- a second protein chain consisting essentially of, from its N-terminus to its C-terminus:
- a region A′ having the structure of the variable domain of the light chain of an immunoglobulin, said region A′ comprising the CDRs of the light chain of said parent antibody;
- a region B identical to the region B of the first polypeptide.
Dependencies are inferred from the claim text.