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AssigneeChung-Ang University Industry-Academy Cooperation Foundation
InventorsWon Yong Kim, In Sik Chung, Jong-Bum Kim, Dong-Hwa Shon, Van Thai Than, Jang Won Yoon, Joo Hyoung Park, In-Hyuk Paek
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Disclosed are a construct for expressing a rotavirus antigen complex loaded with a heterologous virus epitope, a vaccine composition containing the rotavirus antigen complex, a virus-like particle of rotavirus containing the rotavirus antigen complex, and a vaccine composition containing the virus-like particle of rotavirus. According to the present disclosure, an antigen complex containing a rotavirus antigen as well as a heterologous virus epitope and a virus-like particle of rotavirus containing the antigen complex can be produced in large scale at low cost. Thus, the present disclosure may be applied for research and development of novel complex vaccines for rotavirus and heterologous virus.
A rotavirus antigen complex in which a heterologous virus antigen and a rotavirus antigen are linked.
A method of vaccination comprising administering to a subject in need thereof an effective amount of a vaccine composition which comprises a recombinant rotavirus antigen complex wherein a heterologous virus antigen and a rotavirus antigen are linked.
A method of vaccination comprising administering to a subject in need thereof an effective amount of a vaccine composition which comprises a virus-like particle of rotavirus having (i) polypeptides of VP2, VP4 and VP6 of rotavirus;
Dependencies are inferred from the claim text.