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US 2011/0311442 A1Published application
Direct cellular energy delivery system
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorsWilliam D. Ehringer, Sufan Chien
Life of this patent
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Abstract
A lipid vesicle comprising a phospholipid which is a stable vesicle former and at least one unstable vesicle forming member, wherein the unstable vesicle forming member is selected from the group consisting of a polar lipid which is not a stable vesicle former, a PEG, a raft former and a fusion protein is provided. The vesicle can further comprise a biomolecule, such as for example ATP. Methods of using the vesicle for delivery of biomolecules are also provided.
Claims53
A vesicle, comprising:
- (a) a phospholipid which is a stable vesicle former;
- and
- (b) at least one unstable vesicle forming member, wherein the unstable vesicle forming member is selected from the group consisting of a PEG, a raft former, fusion protein, and a polar lipid having the structure of formula (I)
- X-L-(Z)2 (I)
- wherein X is A or has a structure of formula (II)
- B is a cation or an alkyl group;
- A is H or an alkyl group;
- when X has the structure of formula (II) and A is H, B is a cation;
- L is an alkyl group further missing two or three hydrogen atoms, or has a structure selected from the group consisting of formulas (VIII), (IX) or (X)
- and
- each Z is independently H, E, or the structure of formula (XI),
- wherein E is an alkyl or alkenyl, and when one Z is H, the other Z is not H;
- and
- wherein the vesicle is unilamellar.
11 more elements
A vesicle, comprising:
- a biomolecule;
- soy phosphatidylcholine;
- and
- DOTAP,
- wherein the vesicle is unilamellar.
2 more elements
A vesicle, comprising:
- a biomolecule;
- DOPC;
- and
- DOTAP,
- wherein the vesicle is unilamellar.
2 more elements
Dependencies are inferred from the claim text.