One-Part Moisture-Curable Tissue Sealant
OwnerEric J. Beckmaninventor
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Abstract
A tissue sealant is described that includes the reaction product of (a) a polyol having at least two groups capable of reacting with an alkoxy silane and (b) an alkoxy silane having the formula: (R1R2R3)—Si—CH2—Z where (i) Z is an —OH, —SH, —NCO, or —NHR4 group, where R4 is hydrogen or an alkyl group; and (ii) each R1, R2, and R3, independently, is H, an alkoxy group, an alkyl group, a heteroalkyl group other than an alkoxy group, an aryl group, or a heteroaryl group, with the proviso that at least two of R1, R2, and R3 are alkoxy groups. The tissue sealant is moisture-curable and biodegradable in a physiological environment.
Claims25
A tissue sealant comprising the reaction product of:
- (a) a polyol having at least two groups capable of reacting with an alkoxy silane;
- and
- (b) an alkoxy silane having the formula:
- (R1R2R3)—Si—CH2—Z where:
- (i) Z is an —OH, —SH, —NCO, or —NHR4 group, where R4 is hydrogen or an alkyl group;
- and
- (ii) each R1, R2, and R3, independently, is H, an alkoxy group, an alkyl group, a heteroalkyl group other than an alkoxy group, an aryl group, or a heteroaryl group, with the proviso that at least two of R1, R2, and R3 are alkoxy groups, wherein the tissue sealant is moisture-curable and biodegradable in a physiological environment.
Dependencies are inferred from the claim text.