Systems and Methods to Treat Cardiac Pacing Conditions
AssigneeMedtronic, Inc.
InventorsVinod Sharma, Xiaohong Qiu
Life of this patent
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Abstract
The method may include administering to a subject in need thereof an effective amount of an HCN polynucleotide. The HCN polynucleotide includes a nucleotide sequence encoding an HCN polypeptide having channel activity. The amino acid sequence of the HCN polypeptide and the amino acid sequence of a reference polypeptide have at least 80% identity, where the reference polypeptide begins with an amino acid selected from amino acids 92-214 and ends with an amino acid selected from amino acids 723-1188 of SEQ ID NO:8. An example of a reference polypeptide is amino acids 214-723 of SEQ ID NO:8. The HCN polynucleotide may be DNA or RNA.
Claims26
A method comprising:
- identifying a distal end of a catheter at a tissue site of a patient;
- delivering a fluid or polymer that contains an HCN polynucleotide comprising a nucleotide sequence encoding an HCN polypeptide having channel activity, wherein the amino acid sequence of the HCN polypeptide and the amino acid sequence of a reference polypeptide have at least 80% identity, the reference polypeptide beginning with an amino acid selected from amino acids 92-214 and ending with an amino acid selected from amino acids 723-1188 of SEQ ID NO:8 to the tissue site of the patient via the catheter.
Dependencies are inferred from the claim text.