Biomaterials for tissue replacement
AssigneeThe Trustees of the University of Pennsylvania
InventorsSteven B. Nicoll, Simone S. Stalling, Anna T. Reza
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Abstract
This invention relates to biomaterial compositions, methods and kits for producing hydrogels with tunable physico-chemical properties. Specifically, the invention relates to producing cellulosic hydrogels having optimized physico-chemical properties enabling support of cell growth or as replacement or filler for tissue repair, reconstruction or augmentation.
Claims43
A biomaterial composition comprising a cellulose derivative polymer wherein an unprotected group on the cellulose derivative polymer backbone is substituted with a redox-crosslinkable group or a covalently bound photocrosslinkable group.
A method of modifying a physico-chemical property of a cellulose derivative polymer biomaterial comprising the step of covalently substituting an unprotected group on the cellulose derivative polymer backbone with photocrosslinkable groups, or redox-crosslinkable groups;
- in the presence of a photoinitiator, cross-linking the biomaterial;
- and forming a hydrogel from the substituted cellulose derivative polymer.
A kit for the reconstruction, repair or augmentation of a soft tissue, in a subject, comprising a biomaterial composition, the composition comprising an injectible polymer suspension wherein the polymer suspension comprises a methacrylate-substituted cellulose derivative polymer photocrosslinkable or redox-crosslinkable;
- a needle portion that is adapted for insertion under the surface of the skin, a plurality of syringes that hold the composition;
- an electromagnetic radiation source;
- and instructions.
Dependencies are inferred from the claim text.