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US 2011/0301243 A1Published application
Novel method
AssigneeGlaxoSmithKline LLC
InventorsGeoffrey Douglas Clarke, Timothy James Grattan, Ian Burnett
Life of this patent
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AssigneeGlaxoSmithKline LLC
InventorsGeoffrey Douglas Clarke, Timothy James Grattan, Ian Burnett
Estimating the term…
The present invention is directed to a novel method for reducing intrapatient variability in pharmaceutically active agent which is suitably not absorbed in the stomach, such as paracetamol, containing formulations in patients having gastric dysmotility, or a method of improving analgesia in a diabetic patient, or improving absorption of an active agent is a patient with gastric dysmotility, which methods comprises administering orally to said patient in need thereof a pharmaceutical dosage form comprising a first active agent, calcium carbonate, at least one first binding agent, and at least one disintegrating agent as intragranular components in the form of a granulate, and as an extragranular component at least one hydrophilic colloid, an optionally a second binding agent, calcium carbonate, a super disintegrant, and a second active agent.
A method for reducing intrapatient variability in paracetamol containing formulations in patients having gastric dysmotility comprising administering to said patient in need thereof an orally administered pharmaceutical dosage comprising a first active agent, calcium carbonate, at least one first binding agent, and at least one disintegrating agent as intragranular components in the form of a granulate, and as an extragranular component at least one hydrophilic colloid, an optionally a second binding agent, calcium carbonate, super disintegrant, and a second active agent.
A method for improving analgesia in a diabetic comprising administering to said patient in need thereof an orally administered pharmaceutical dosage comprising a first active agent, calcium carbonate, at least one first binding agent, and at least one disintegrating agent as intragranular components in the form of a granulate, and as an extragranular component at least one hydrophilic colloid, an optionally a second binding agent, calcium carbonate, super disintegrant, and a second active agent.
A method for improving absorption of paracetamol in a patient with gastric dysmotility comprising administering to said patient in need thereof an orally administered pharmaceutical dosage comprising a first active agent, calcium carbonate, at least one first binding agent, and at least one disintegrating agent as intragranular components in the form of a granulate, and as an extragranular component at least one hydrophilic colloid, an optionally a second binding agent, calcium carbonate, super disintegrant, and a second active agent.
A method for improving analgesia in a diabetic comprising administering to said patient in need thereof an orally administered pharmaceutical dosage comprising
Dependencies are inferred from the claim text.