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US 2011/0301221 A1Published application
Diagnosis, prognosis and treatment of glioblastoma multiforme
AssigneeSwedish Health Services
InventorsBiaoyang Lin, Gregory Foltz
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AssigneeSwedish Health Services
InventorsBiaoyang Lin, Gregory Foltz
Estimating the term…
The present invention in one aspect relates generally to the identification, provision and use of a plurality of biomarkers to provide risk assessment of a subject having glioblastoma multiforme, and products and processes related thereto. In one aspect, a novel plurality of biomarkers as described herein is provided to determine a risk of glioblastoma multiforme. In another aspect, a novel plurality of biomarkers as described herein is provided to diagnose a subject having glioblastoma multiforme. In yet another aspect are methods for treating a subject having glioblastoma multiforme by administering one or more therapeutic regimens for glioblastoma multiforme. In yet another aspect are nucleic acid arrays comprising nucleic acid probes that hybridize to one or more glioblastoma multiforme genes.
A method of diagnosing whether a subject has, or is at risk for developing, a brain tumor, comprising:
A method for identifying a subject having a brain tumor, comprising determining expression profiles of no more than five to five hundred genes in a biological sample comprising cells from a subject, wherein at least 20% of the genes are selected from the brain tumor marker genes listed in Table 1.
A method of determining the prognosis of a subject with a brain tumor comprising measuring the level of at least one miRNA selected from Table 1 in a test biological sample from said subject, wherein the miRNA expression level is associated with an adverse prognosis;
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A method of treating a brain tumor in a subject, comprising:
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Dependencies are inferred from the claim text.