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US 2011/0301079 A1Published application
Neuromedin u receptor agonists and uses thereof
AssigneesInstituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A., Merck Sharp & Dohme Corp.
InventorsDonald J. Marsh, Antonello Pessi, Elisabetta Bianchi, Paolo Ingallinella, Andrea Peier, Alessandro Pocai
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Abstract
Neuromedin U receptor agonists for use in the treatment of metabolic disorders such as obesity and diabetes are disclosed. In particular, disclosed are neuromedin U receptor agonists that comprise neuromedin S (NMS).
Claims21
A neuromedin U receptor agonist, which has the formula
- Z1-peptide-Z2
- wherein the peptide has the amino acid sequence ILQRG SGTAA VDFTK KDHTA TWGRP FFLFR PRN (SEQ ID NO:1), wherein the peptide can have one or more insertions or substitutions of the amino acid sequence with an alternative amino acid and wherein the peptide can have one or more deletions of the amino acid sequence;
- Z1 is an optionally present protecting group that, if present, is joined to the N-terminal amino group;
- and Z2 is NH2 or an optionally present protecting group that, if present, is joined to the C-terminal carboxy group;
- and pharmaceutically acceptable salts thereof.
2 more elements
A method for treating a metabolic disorder in an individual comprising:
- administering to the individual a therapeutically effective amount of a neuromedin U receptor agonist that has the formula
- Z1-peptide-Z2
- wherein the peptide has the amino acid sequence ILQRG SGTAA VDFTK KDHTA TWGRP FFLFR PRN (SEQ ID NO:1), wherein the peptide can have one or more insertions or substitutions of the amino acid sequence with an alternative amino acid and wherein the peptide can have one or more deletions of the amino acid sequence;
- Z1 is an optionally present protecting group that, if present, is joined to the N-terminal amino group;
- and Z2 is NH2 or an optionally present protecting group that, if present, is joined to the C-terminal carboxy group;
- and pharmaceutically acceptable salts thereof.
3 more elements
21-24. (canceled)
Dependencies are inferred from the claim text.