Identifying antigen clusters for monitoring a global state of an immune system
AssigneeYeda Research and Development Co. Ltd.
InventorsIrun R. COHEN, Eytan Domany, Francisco Javier Quintana, Guy Hed, Gad Getz
Life of this patent
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Abstract
Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.
Claims19
An article of manufacture comprising a surface and antigens being arranged on said surface, each in an independent addressable location, wherein said antigens comprise antigens of cluster 5 comprising Insulin and Aldolase, cluster 14 comprising Cartilage extract, cluster 26 comprising Histone II A, Lysine, Arginine, Laminin, Collagen X, Fibrinogen and Collagen VII, cluster 47 comprising Collagen X and Insulin and cluster 66 comprising Cardiolipin and Cartilage.
An article of manufacture comprising a surface and antigens being arranged on said surface, each in an independent addressable location, wherein said antigens comprise antigens of cluster 19 comprising KLH, Glucocerebrosidase, Actin, spectrin, Vimentin, Fibronectin, Collagen, Collagen I, Collagen IX, Peroxidase, Tyrosinase, Enolase, Ribonuclease, H Albumin, R Albumin, Fibrin, H IgM, HSP60, p277, C9, N4, Brain Ext, Ec27 and P278.
An article of manufacture comprising a surface and antigens being arranged on said surface, each in an independent addressable location, wherein said antigens comprise antigens of cluster 9 comprising IL10 and IL4 and cluster 13, comprising Catalase, Hemoglobin A, Myoglobulin and Insulin.
Dependencies are inferred from the claim text.