Signal sequence-independent pix phage display
AssigneeNextera AS
InventorGeir Åge Løset
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Abstract
The present invention provides an alternative scaffold for peptides displayed on filamentous phages through novel fusion proteins primarily originating from pIX. Libraries of filamentous phages can be created from fusion proteins, and a phage display system comprising a phagemid and a helper phage is a part of the invention. An aspect of the invention is a kit containing a phage display system comprising a phagemid that contains a nucleic acid encoding the fusion protein of the invention and a helper phage.
Claims13
A phage genome or a phagemid comprising a nucleic acid encoding a pIX fusion protein originating from a filamentous phage, wherein the fusion protein does not comprise a prokaryotic N-terminal signal sequence.
2-11. (canceled)
Dependencies are inferred from the claim text.