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US 2011/0301050 A1Published application
Dna hypermethylation brain cancer markers
OwnerGerd P. Pfeifer, Xiwei Wu +1inventors
InventorsGERD P. PFEIFER, XIWEI WU, TIBOR A. RAUCH
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OwnerGerd P. Pfeifer, Xiwei Wu +1inventors
InventorsGERD P. PFEIFER, XIWEI WU, TIBOR A. RAUCH
Estimating the term…
One aspect of the present disclosure relates to a composition comprising a DNA hypermethylation brain cancer marker on acellular DNA of a human subject. DNA hypermethylation brain cancer markers (or DNA hypermethylation markers) are frequently methylated in the DNA of brain cells and acellular DNA of individuals suffering from brain cancer. These DNA hypermethylation markers are not frequently methylated in the DNA of brain cells and acellular DNA of individuals who do not suffer from brain cancer. Another aspect of the present disclosure relates to a method of diagnosing brain cancer in a human subject comprising providing a sample containing acellular DNA from the human subject, determining whether one or more DNA hypermethylation markers on the acellular DNA are hypermethylated, and diagnosing brain cancer when the DNA hypermethylation markers are hypermethylated.
A composition of matter comprising a DNA hypermethylation brain cancer marker on acellular DNA of a human subject selected from the group consisting of SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5, SEQ ID NO. 6, SEQ ID NO. 7, SEQ ID NO. 8, SEQ ID NO. 9, SEQ ID NO. 10, and combinations thereof.
A method of diagnosing a brain tumor in a human subject comprising:
Dependencies are inferred from the claim text.