Methods and compositions for delivering polynucleotides
AssigneeGencia Corporation
InventorShaharyar Khan
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Abstract
Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein transduction domain operably linked to a targeting signal. Methods for modifying the genome of non-nuclear organelles are also provided.
Claims14
1-49. (canceled)
A transcription factor A-mitochondrial (TFAM) fusion protein comprising three different domains, wherein each domain is independently selected from the group consisting of a protein transduction domain, a mitochondrial localization signal, and a mature transcription factor A-mitochondrial (TFAM) polypeptide.
A transcription factor A-mitochondrial (TFAM) fusion protein comprising three different domains, wherein each domain is independently selected from the group consisting of a protein transduction domain, a mitochondrial localization signal, and a transcription factor A-mitochondrial (TFAM) polypeptide comprising amino acids 63-128 and 168-229 of SEQ ID NO:210.
A transcription factor A-mitochondrial (TFAM) fusion protein comprising (a) a protein transduction domain;
- (b) a mitochondrial localization signal;
- and (c) a mature TFAM polypeptide, or fragment thereof comprising an HMG box of TFAM, wherein the fragment can bind to a polynucleotide.
Dependencies are inferred from the claim text.