Therapeutic Inhibitor of Vascular Smooth Muscle Cells
OwnerLawrence L. Kunz, Peter G. Andersoninventors
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Abstract
Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.
Claims23
-79. (canceled)
A method of maintaining vessel luminal area, comprising administering to a blood vessel a sustained release dosage form comprising a cytostatic amount of taxol or a taxol analog effective to inhibit or reduce stenosis or restenosis of a blood vessel, wherein the cytostatic amount of taxol or taxol analog is an amount that exerts minimal protein synthesis inhibition and cytotoxicity on vascular smooth muscle cells.
A method of maintaining vessel luminal area, comprising administering to a blood vessel a medical device comprising a sustained release dosage form comprising a cytostatic amount of taxol or a taxol analog effective to inhibit or reduce stenosis or restenosis upon placement of the device, wherein the cytostatic amount of taxol or taxol analog is an amount that exerts minimal protein synthesis inhibition and cytotoxicity on vascular smooth muscle cells.
A sustained release dosage form comprising a cytostatic amount of taxol or a taxol analog effective to inhibit or reduce stenosis or restenosis of a blood vessel, wherein the cytostatic amount of taxol or taxol analog is an amount that exerts minimal protein synthesis inhibition and cytotoxicity on vascular smooth muscle cells.
Dependencies are inferred from the claim text.