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US 2011/0300208 A1Published application
Segmented pharmaceutical dosage forms
OwnerLawrence Solomon, Allan S. Kaplaninventors
Life of this patent
Estimating the term…
Abstract
A pharmaceutical tablet adapted for accurate division of a dose of a drug into two or more smaller doses, which tablet has two or more segments.
Claims16
A compressed, layered pharmaceutical dosage form having its height greater than its width and configured as
- a first segment comprising a composition containing an effective amount of one or more drugs, and
- a second segment contacting said first segment, said second segment comprising an immediate release composition substantially free of drug and forming an inner inactive segment that is adjacent above said first segment and below
- a third segment comprising a composition containing an effective amount of a drug or drugs, wherein
- the compositions of said first and third segments and the drug or drugs contained in said compositions are physically and chemically compatible with one another, and wherein
- the terms “height” and “width” and “above” and “below” refer to the position of said dosage form in a tablet die after tablet compression has been completed but before said tablet has been ejected from said die.
2 more elements
A compressed, layered pharmaceutical dosage form having its height greater than its width and configured as
- a first segment comprising a composition containing an effective amount of one or more drugs, and
- a second segment contacting said first segment, said second segment comprising an immediate release composition substantially free of drug and forming an inner inactive segment that is adjacent above said first segment and below
- a third segment comprising a composition containing an effective amount of a drug or drugs, wherein said dosage form
- i) lacks a semi-permeable membrane coating,
- ii) lacks an osmotically active component to alter the release of drug, or
- iii) lacks a drug over-coating,
- wherein the terms “height” and “width” and “above” and “below” refer to the position of said dosage form in a tablet die after tablet compression has been completed but before said tablet has been ejected from said die.
4 more elements
A compressed, layered pharmaceutical dosage form having its height greater than its width and configured as
- a first segment comprising a composition containing an effective amount of one or more drugs (A),
- a second segment contacting said first segment, said second segment comprising an immediate release composition substantially free of drug and forming an inner inactive segment that is adjacent above said first segment and below
- a third segment comprising a composition containing an effective amount of a drug or drugs, wherein
- dosage form comprises a tablet structure selected from the group consisting of A-I-A;
- A-I-B;
- A-I-A-I;
- A-I-B-I;
- A-I-B-I-A;
- A-I-B-I-B;
- A-I-B-I-C;
- and A-B-I-C wherein
- “A” represents an active segment comprising a first active drug or combination of more than one active drug;
- “B” represents an active segment comprising a second active drug or combination of active drugs;
- “C” represents an active segment comprising a third active drug or combination of drugs;
- and
- “I” represents an inactive segment substantially free of active drug or combination of active drugs, and
- wherein the terms “height” and “width” and “above” and “below” refer to the position of said dosage form in a tablet die after tablet compression has been completed but before said tablet has been ejected from said die.
14 more elements
The dosage form of claim 78 wherein the inert or pharmaceutically inactive composition is a capsule.
Dependencies are inferred from the claim text.