Vaccines against chlamydial infection
AssigneesGlaxosmithkline Biologicals SA, Corixa Corporation
InventorsMark ALDERSON, Ajay BHATIA, Yves LOBET, Brenda MAISONNEUVE, Jean-Francois L. MAISONNEUVE, Martine MARCHAND, Pascal METTENS, Florence Bernadette NOZAY, Peter PROBST, Yasir A. SKEIKY, Samira H. SKEIKY
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Abstract
The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
Claims25
A composition comprising
- i. a combination of two or more Chlamydia proteins or immunogenic fragments thereof selected from the group consisting of Ct-858, Ct-875, Ct-089, passenger domain of PmpG (PmpGpd) and passenger domain of PmpD (PmpDpd) or polynucleotides encoding them, and
- ii. a pharmaceutically acceptable carrier.
A composition comprising one of the following combinations of Chlamydia polypeptides or immunogenic fragments thereof:
- a) Two out of:
- Ct-858, Ct-875, Ct-089, PmpDpd, PmpGpd;
- b) Ct-858, Ct-875, Ct-089;
- and
- c) PmpDpd, Ct-858, Ct-875, Ct-089.
A method for the treatment or prevention of Chlamydial infection by a second Chlamydia trachomatis serovar, comprising the administration of an immunogenic composition comprising one or more Chlamydial proteins or immunogenic fragments thereof selected from the list consisting of Ct-089, Ct-858 and Ct-875, and which are derived from a first Chlamydia trachomatis serovar different from the second serovar.
A method for determining prior Chlamydial infection in an individual comprising:
- (i) obtaining a sample from the individual;
- (ii) contacting said sample with a combination of two or more Chlamydia proteins or immunogenic fragments thereof selected from Ct-858, Ct-875, Ct-089, passenger domain of PmpG (PmpGpd) and passenger domain of PmpD (PmpDpd);
- (iii) quantifying the sample response.
Dependencies are inferred from the claim text.