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US 2011/0300190 A1Published application
Compound, composition and uses thereof
AssigneeKrisani Biosciences (P) Ltd
InventorMAHESH KANDULA
Life of this patent
Estimating the term…
Abstract
The disclosure herein provides a compound of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, and hydrates thereof. The steps of synthesis of compound of formula I is described. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for oral administration, transdermal administration, or injection. Such compositions may be used to treatment of metabolic condition or neurodegenerative disorders or its associated complications.
Claims14
A compound, comprising;
- a pharmaceutically acceptable compound of formula I:
- Wherein, R1, R2 each independently represents at least one of hydrogen, methyl, amine, cyclohexyl methyl ether, butoxy, propoxy, thiol, alkyl, alkyl thiol, acetyl thiol, disulfide, acyl, acylalkyl, alkenyl, alkylthioalkyl, alkynyl, alkoxyaryl, alkoxyalkyl, aryl, aralkyl, aryloxyalkyl, arylthioalkyl, cycloalkyl, ether, ester, heteroaryl, heterocyclyl, lower alkyl, sulfone, sulfoxide, or hydroxyalkyl;
- R2 also independently represents at least one of hydrogen, carboxyl, amine, —NH—CO—NH—, —NH—CO—CH2—NH—, —NH—CO—, R—COO—R1, thiol, disulfide,
- R3 independently represents at least one of at least one of
1 more element
A method of synthesis for a compound of formula I, comprising:
- mixing lithium aluminum hydride in THF as solution with a suspension of eicosapentaenoic acid in THF at 0° C.;
- warming the reaction mixture to room temperature;
- maintaining the room temperature for overnight;
- quenching the reaction mixture with saturated sodium sulphate and then extracting with ethyl acetate;
- separating the organic layer and washing with brine;
- drying the washed layer over anhydrous Na2SO4 and evaporating under reduced pressure to make a compound 2;
- and
- purifying the compound 2 by column chromatography.
5 more elements
A kit;
- comprising:
- a pharmaceutically acceptable salt of compound of formula I comprising:
- a pharmaceutically acceptable compound of formula I:
- Wherein, R1, R2 each independently represents at least one of hydrogen, methyl, amine, cyclohexyl methyl ether, butoxy, propoxy, thiol, alkyl, alkyl thiol, acetyl thiol, disulfide, acyl, acylalkyl, alkenyl, alkylthioalkyl, alkynyl, alkoxyaryl, alkoxyalkyl, aryl, aralkyl, aryloxyalkyl, arylthioalkyl, cycloalkyl, ether, ester, heteroaryl, heterocyclyl, lower alkyl, sulfone, sulfoxide, or hydroxyalkyl;
- R2 also independently represents at least one of hydrogen, carboxyl, amine, —NH—CO—NH—, —NH—CO—CH2—NH—, —NH—CO—, R—COO—R1, thiol, disulfide,
- R3 independently represents at least one of at least one of
3 more elements
Dependencies are inferred from the claim text.