Immunogenic escherichia coli heat stable enterotoxin
AssigneeBoard of Trustees of Michigan State University
InventorMahdi A. Saeed
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Abstract
The present invention relates to methods and compositions for the treatment and prevention of diarrhea and diarrheal related diseases and disorders in both animals and humans. In some embodiments, the invention relates to the treatment of said diarrhea and diarrheal related diseases and disorders with a vaccine. In still further embodiments, the invention relates to the treatment of constipation using the disclosed methods and compositions.
Claims20
A vaccine comprising heat-stable enterotoxin protein from Escherichia coli comprising an amino terminus, a cross-linker comprising first and second ends, and a carrier protein, wherein said first end of said cross-linker is covalently attached to said amino terminus of said enterotoxin and said second end of said cross-linker is covalently attached to said carrier protein.
A method of producing a STa-neutralizing antibody in egg laying hens, comprising:
- a) immunizing said hens with said Sta antigen;
- and b) collecting eggs, said eggs containing antibody reactive with said antigen.
Dependencies are inferred from the claim text.