Treatment of airway hyperreactivity
AssigneesChildren's Medical Center Corporation, President and Fellows of Harvard College, The Board of Trustees of the Leland Stanford Junior University
InventorsDale T. Umetsu, Muriel Pichavant, Rosemarie Helena DeKruyff-Umetsu, Everett Hurteau Meyer, Stephanie Ann Shore
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Abstract
The invention provides strategies for treating and preventing airway hyperreactivity and non-allergic asthma comprising antagonizing IL-17 activity and/or production by iNKT cells. Provided herein is a method of diagnosing non-allergic asthma and airway hyperreactivity comprising neutrophils quantification in sputum.
Claims16
1-14. (canceled)
A method of treating non-allergic asthma in an individual comprising:
- a. selecting an individual diagnosed with non-allergic asthma;
- and
- b. administering to said individual an effective amount of IL-17 antagonist.
A method of treating an individual at risk of non-allergic asthma comprising:
- a. measuring the level of neutrophils in a sample of sputum from an individual;
- b. administering to said individual an effective amount of an IL-17 antagonist when the level of neutrophils is above a predetermined level.
Dependencies are inferred from the claim text.