Systems and methods for enhancing vaccine efficacy
AssigneeUniversity of Rochester
InventorsRichard P. Phipps, Tatiana Margarita Garcia-Bates
Life of this patent
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Abstract
Pharmaceutical compositions of the invention include an antigen or a nucleic acid molecule encoding the antigen; one or both of a PPAR ligand and an RxR ligand; and a pharmaceutically suitable carrier. The pharmaceutical composition can optionally include a mitogen or other additives. Also disclosed are methods of inducing B cell differentiation and promoting an immune response against an antigen.
Claims31
A method of promoting an immune response against an antigen comprising:
- first administering a PPAR ligand, an RxR ligand, or a combination thereof, and optionally a mitogen, to a patient under conditions effective to promote an immune response against an antigen of interest.
(canceled)
(canceled)
A method of inducing B cell differentiation comprising:
- contacting a B cell with either a PPAR ligand, an RxR ligand, or a combination thereof, and optionally with a mitogen, whereby said contacting is effective to induce B cell differentiation into plasma cells.
20-21. (canceled)
A pharmaceutical composition comprising:
- an antigen or a nucleic acid molecule encoding the antigen;
- both PPAR ligand and an RxR ligand;
- an adjuvant, a mitogen, or both;
- and
- a pharmaceutically suitable carrier.
30-40. (canceled)
42-59. (canceled)
Dependencies are inferred from the claim text.