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US 2011/0300097 A1Published application
Method And Composition For The Treatment Of Moderate To Severe Keratoconjunctivitis Sicca
OwnerAhmed H. Al-Qahtaniinventor
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Abstract
The present invention relates to topical ophthalmic compositions for treating or preventing epithelial lesions or ophthalmic disorders, including dry eye or keratoconjunctivitis sicca.
Claims42
A method for treating an epithelial lesion of the eye or ophthalmic disorder comprising:
- topically administering an ophthalmic composition comprising conditioned media, or concentrate of said media, from cultured conjunctiva cells or cultured corneal cells in combination with a pharmaceutically acceptable carrier to the ocular surface or immediate vicinity of an eye of a subject in need thereof.
A topical ophthalmic composition for treating or preventing epithelial lesions or ophthalmic disorders comprising:
- i) conditioned media or cell free extract or concentrate thereof from cultured conjunctiva cells or cultured corneal cells and
- ii) a water-soluble viscosity building agent, wherein said conditioned media is generated by incubating a nutrient medium with said cells under conditions which promote secretion of at least one human growth factor into the nutrient medium.
A kit comprising:
- i) at least one container;
- ii) an ophthalmic composition comprising conditioned media or cell free extract or concentrate thereof from cultured conjunctiva cells or corneal cells and a water-soluble viscosity building agent;
- and
- iii) instructions which provide a) methods of mixing the composition and water-soluble building agent and/or b) methods of applying the composition to treat or prevent dry-eye.
1 more element
Dependencies are inferred from the claim text.