Targeting npr-c in angiogenesis and atherosclerosis with a c-type atrial natriuretic factor (canf)-comb nanocomplex
AssigneeWashington University
InventorsPamela K. WOODARD, Yongjian LIU, Eric PRESSLY, Dana ABENDSCHEIN, Craig J. HAWKER, Michael J. WELCH
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Abstract
Tracers are disclosed comprising an amphiphilic comb-like nanostructure conjugated with an oligopeptide such as a fragment of a natriuretic peptide, and a signaling moiety such as a positron-emitting radionuclide. A fragment of a natriuretic peptide comprises Arg-Ile-Asp-Arg-Ile (SEQ ID NO:1). Further disclosed are methods of imaging distribution of C-type atrial natriuretic peptide receptors and methods of imaging angiogenesis and atherosclerosis by PET scanning or MRI using a tracer.
Claims21
A tracer comprising:
- an amphiphilic comb-like nanostructure conjugated with an oligopeptide comprising a fragment of a natriuretic peptide, wherein the fragment comprises Arg-Ile-Asp-Arg-Ile (SEQ ID NO:1);
- and
- a positron-emitting radionuclide.
A method of determining distribution of C-type atrial natriuretic peptide receptors in a subject, comprising:
- administering to the subject a tracer comprising a) an amphiphilic comb-like nanostructure conjugated with an oligopeptide comprising a fragment of a natriuretic peptide, wherein the fragment comprises Arg-Ile-Asp-Arg-Ile (SEQ ID NO:1) and b) a positron-emitting radionuclide;
- and
- subjecting the subject to positron emission tomography scanning.
A method in accordance with claim 16, wherein the positron-emitting radionuclide is a copper-64.
A method of imaging angiogenesis or atherosclerosis in a subject, comprising:
- administering to the subject a tracer comprising a) an amphiphilic comb-like nanostructure conjugated with an oligopeptide comprising a fragment of a natriuretic peptide, wherein the fragment comprises Arg-Ile-Asp-Arg-Ile (SEQ ID NO:1) and b) a positron-emitting radionuclide;
- and
- subjecting the subject to positron emission tomography scanning.
Dependencies are inferred from the claim text.