Methods for increasing efficacy of radioimmunotherapy of melanoma
OwnerEkaterina Dadachova, Arturo Casadevallinventors
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Abstract
Methods are disclosed for using agents and treatments that cause the release of melanin from melanin-containing melanomas to increase the efficacy of therapy and imaging of the melanomas with radiolabeled anti-melanin antibodies and peptides.
Claims27
A method for treating a melanin-containing melanoma in a subject which comprises (a) administering to the subject an agent or treatment that releases melanin from melanoma cells, and (b) then administering to the subject an amount of a radiolabeled anti-melanin antibody and/or radiolabeled anti-melanin peptide effective to treat the melanoma.
A method for imaging a melanin-containing melanoma in a subject which comprises (a) administering to the subject an agent or treatment that releases melanin from melanoma cells, and (b) then administering to the subject an amount of a radiolabeled anti-melanin antibody and/or radiolabeled anti-melanin peptide effective to image the melanoma.
Dependencies are inferred from the claim text.