Antigen Specific Tregs and related compositions, methods and systems
OwnerJune L. Round, Sarkis K. Mazmanianinventors
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Abstract
Antigen specific regulatory T cells are described and related compositions, methods and systems. Methods to generate an antigen specific anti-inflammatory regulatory T cell is provided, the method comprising contacting either a T cell or an antigen presenting cell with a zwitterionic polysaccharide conjugated to the antigen for a time and under condition to generate an antigen specific regulatory T cell that is capable of inhibiting a pro-inflammatory response against the antigen.
Claims30
A method to generate an antigen specific anti-inflammatory regulatory T cell, the method comprising contacting either:
- a) a T cell with a zwitterionic polysaccharide conjugated to the antigen for a time and under condition to generate an antigen specific regulatory T cell that is capable of inhibiting a pro-inflammatory response against the antigen;
- or
- b) an antigen presenting cell with a zwitterionic polysaccharide conjugated to the antigen for a time and under condition to generate an antigen specific regulatory T cell that is capable of inhibiting a pro-inflammatory response against the antigen.
A method of inhibiting antigen specific inflammation in an individual, the method comprising treating the individual with a zwitterionic polysaccharide conjugated to a specific antigen for a time and under conditions to induce an antigen specific anti-inflammatory regulatory T cell in the individual.
A method to generate an antigen specific anti-inflammatory regulatory T cell, the method comprising contacting either:
- a) a T cell with a zwitterionic polysaccharide for a time and under condition to generate an antigen specific regulatory T cell that is capable of inhibiting a pro-inflammatory response against the antigen;
- or
- b) an antigen presenting cell with a zwitterionic polysaccharide for a time and under condition to generate an antigen specific regulatory T cell that is capable of inhibiting a pro-inflammatory response against the antigen.
Dependencies are inferred from the claim text.