Generation of virus-like particles and use as panfilovirus vaccine
OwnerSina Bavari, Kelly L. Warfield +1inventors
InventorsSina Bavari, Kelly L. Warfield, Warren Kalina
Life of this patent
Estimating the term…
Abstract
In this application are described filovirus-like particles for both Ebola and Marburg and their use as a diagnostic and therapeutic agent as well as a filovirus vaccine. Also described is the association of Ebola and Marburs with lipid rafts during assembly and budding, and the requirement of functional rafts for entry of filoviruses into cells.
Claims21
A chimeric filovirus virus like particle, VLP, comprising filovirus matrix protein VP40, and a chimeric envelope glycoprotein, GP, wherein said GP is comprised of GP1 from a first filovirus and GP2, from a second filovirus.
A chimeric VLP-producing cell comprising a mammalian cell expressing said VLP.
A chimeric VLP-producing cell comprising an insect cell expressing said VLP.
Dependencies are inferred from the claim text.