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US 2011/0269202 A1Published application
Genetically Engineered Yeast for the Production of Biofuels
AssigneeNew England Biolabs, Inc.
InventorsChristopher H. Taron, Paul A. Colussi
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Abstract
Compositions and methods are provided for generating biofuels by fermentation from carbon sources other than glucose using genetically engineered yeast strains. For example, a Saccharomyces strain which is capable of converting glucose to ethanol but not of metabolizing N-acetyl glucosamine is genetically engineered to utilize N-acetyl glucosamine as a nutrient carbon source.
Claims18
A composition, comprising:
- a genetically engineered yeast cell containing a heterologous DNA encoding at least one enzyme required for N-acetylglucosamine (GlcNAc) metabolism, the genetically modified yeast cell being capable of growing on a nutrient medium wherein the carbon source is GlcNAc such that the yeast cell prior to genetic engineering is not capable of growth on the GlcNAc carbon source.
A method for making a biofuel, comprising:
- modifying a yeast cell preparation that naturally does not metabolize GlcNAc by introducing heterologous DNA into the yeast cell, the heterologous DNA encoding at least one protein required for GlcNAc metabolism;
- providing GlcNAc as a source of nutrient carbon to the modified yeast strain;
- and
- permitting metabolic conversion of the GlcNAc to the biofuel by propagation of the modified yeast cell preparation.
1 more element
Dependencies are inferred from the claim text.