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US 2011/0268713 A1Published application
Variants of Ancestral Uricases and Uses Thereof
AssigneeGeorgia Tech Research Corporation
InventorEric A. Gaucher
Life of this patent
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Abstract
The present invention provides uricases and methods of their production and use in reducing the amount of uric acid in a subject. The present invention further provides methods employing a uricase of this invention in the treatment and/or prevention of hyperuricemia, gout, tumor lysis syndrome and/or hypertension in a subject.
Claims32
A uricase comprising one or more uricase subunits selected from the group consisting of:
- a. a uricase subunit having an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO:8;
- b. a uricase subunit having an amino acid sequence that is at least 96% identical to the amino acid sequence of SEQ ID NO:2;
- c. a uricase subunit having an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:3;
- d. a uricase subunit having an amino acid sequence that is at least 94% identical to the amino acid sequence of SEQ ID NO:4;
- e. a uricase subunit having an amino acid sequence that is at least 94% identical to the amino acid sequence of SEQ ID NO:5;
- f. a uricase subunit having an amino acid sequence that is at least 93% identical to the amino acid sequence of SEQ ID NO:6;
- g. a uricase subunit having an amino acid sequence that is at least 91% identical to the amino acid sequence of SEQ ID NO:7;
- h. a uricase subunit having an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO:1;
- i. a uricase subunit having an amino acid sequence that is at least 98% identical to the amino acid sequence of SEQ ID NO:9;
- and
- j. any combination of the subunits (a)-(i).
8 more elements
An isolated nucleic acid molecule comprising a nucleic acid sequence that encodes one or more uricase subunits selected from the group consisting of:
- a. a uricase subunit having an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO:8;
- b. a uricase subunit having an amino acid sequence that is at least 96% identical to the amino acid sequence of SEQ ID NO:2;
- c. a uricase subunit having an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:3;
- d. a uricase subunit having an amino acid sequence that is at least 94% identical to the amino acid sequence of SEQ ID NO:4;
- e. a uricase subunit having an amino acid sequence that is at least 94% identical to the amino acid sequence of SEQ ID NO:5;
- f. a uricase subunit having an amino acid sequence that is at least 93% identical to the amino acid sequence of SEQ ID NO:6;
- g. a uricase subunit having an amino acid sequence that is at least 91% identical to the amino acid sequence of SEQ ID NO:7;
- h. a uricase subunit having an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO:1;
- i. a uricase subunit having an amino acid sequence that is at least 98% identical to the amino acid sequence of SEQ ID NO:9;
- and
- j. any combination of the subunits (a)-(i).
8 more elements
Dependencies are inferred from the claim text.