Myostatin isoform
AssigneeOrico Limited
InventorsFerenc Jeanplong, Christopher David McMahon
Life of this patent
Estimating the term…
Abstract
The present invention provides splice variants of myostatin that promote muscle growth, and include polynucleotides and polypeptide sequences, constructs comprising the sequences and compositions for regulating muscle growth and treating diseases associated with muscle tissue. The splice variants include the consensus sequence X1 I F L E X2 X3 X4 Q X5 C S I L X6 X7 X8 X9 X10 wherein X1 is I or L, X2 is V or L, X3 is Y, C, G or S, X4 is I or F, X5 is F or L, X6 is G or E, X7 is E or V, X8 is A or T, X9 is A or V and X10 is absent, F or L. The present invention also provides for the use of the present sequences in identifying animals with altered muscle mass, and for use in selective breeding programs to produce animals with altered muscle mass.
Claims16
An isolated polypeptide comprising an amino acid sequence having the formula:
- X1IFLEX2X3X4QX5CSILX6X7X8X9X10
- wherein X1 is I or L, X2 is V or L, X3 is Y, C, G or S, X4 is I or F, X5 is F or L, X6 is G or E, X7 is E or V, X8 is A or T, X9 is A or V and X10 is absent, F or L.
An isolated polypeptide that is selected from:
- (a) a polypeptide comprising an amino acid sequence of any one of SEQ ID NOS:
- 48-95;
- (b) a polypeptide that comprises a fragment or variant of a polypeptide in (a);
- and
- (c) a polypeptide having at least 90% sequence identity with a polypeptide of (a), wherein the polypeptide is capable of promoting myoblast cell growth.
-8. (canceled)
(canceled)
(canceled)
15-34. (canceled)
-44. (canceled)
Dependencies are inferred from the claim text.