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US 2011/0257458 A1Published application
Method of using tumor cell debris to reduce brain tumor recurrence or growth
AssigneeCedars-Sinai Medical Center
InventorsDwain Morris-Irvin, Keith L. Black
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Abstract
The present invention describes compositions comprising tumor cell debris, tumor lysate or tumor antigens and methods of using tumor cell debris, tumor lysate or tumor antigens for stimulating a specific immune response. The compositions may further comprise at least one TLR ligand. The stimulation of the specific immune response may be used to treat tumors, particularly, brain tumors. The treatment method may also reduce the recurrence of a tumor and/or inhibit or slow down the growth of a tumor.
Claims33
A method, comprising:
- providing a composition comprising a substance selected from the group consisting of tumor cell debris, tumor lysate, tumor antigens and combinations thereof, wherein the substance is generated by a method comprising exposing tumor cells to microwave radiation to induce cell death;
- and
- administering the composition to elicit a specific immune response in a mammal in need thereof.
A composition, comprising:
- a quantity of a substance selected from the group consisting of tumor cell debris, tumor lysate, tumor antigens and combinations thereof, wherein the substance is generated by a method comprising exposing tumor cells to microwave radiation to induce cell death;
- and
- a pharmaceutically acceptable carrier.
A kit, comprising:
- a pharmaceutically acceptable excipient adapted for preparing a composition comprising a quantity of a substance selected from the group consisting of tumor cell debris, tumor lysate, tumor antigens and combinations thereof, wherein the substance is generated by a method comprising exposing tumor cells to microwave radiation to induce cell death, for administration to a mammal in need of treatment to reduce the likelihood of tumor recurrence;
- and
- instructions for using the pharmaceutically acceptable excipient to prepare the composition for administration to the mammal.
A method, comprising:
- providing a microwave probe;
- contacting the microwave probe to a tumor to ablate the tumor and generate tumor cell debris or using the microwave probe to deliver microwave radiation to the tumor to generate tumor cell debris to elicit a specific immune response in a mammal in need thereof.
Dependencies are inferred from the claim text.