Perturbed membrane-binding compounds and methods of using the same

A compound represented by the structure as set forth in formula (I):

• including pharmaceutically acceptable salts, hydrates, solvates and metal chelates of the compound represented by the structure as set forth in formula (I) and solvates and hydrates of the salts;
• wherein, one of R or R′ groups is hydrogen, and the other of R or R′ group represents C1, C2, C3, C4, C5, C6, C7, C8, Cg, C10, C11, C12, C13, C14, C15, C16, linear or branched alkyl, linear or branched hydroxy-alkyl, linear or branched fluoro-alkyl, aryl or hetroaryl composed of one or two rings, or combinations thereof;
• n and m each stands for an integer of 0, 1, 2, 3 or 4;
• n and m may be same or different;
• M is selected from null, hydrogen, —O—, —S—, and —N(U), wherein U stands for hydrogen, or C1, C2, C3, or C4 alkyl;
• x, and z each stands independently and is an integer of 0, 1 or 2, where x and z can be the same or different;
• y is an integer of 0, 1 or 2, where when y=2 the substituent R′ may be the same or different at each occurrence;
• and D is hydroxyl.