Process for producing optically active carboxylic acid
AssigneeDaiichi Sankyo Company, Limited
InventorsKoji Sato, Kazuo KUBOTA
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Abstract
It has been demanded to provide a process for industrially producing an intermediate for a compound that exhibits an inhibitory effect on activated blood coagulation factor X and is useful as a preventive and/or therapeutic agent for thrombotic diseases. The present invention provides a process for producing the (R)-α-phenylethylamine salt of (S)-3-cyclohexene-1-carboxylic acid, comprising reacting 3-cyclohexene-1-carboxylic acid and (R)-α-phenylethylamine using a mixed solvent of water and acetone or a mixed solvent of water and ethyl acetate as a solvent.
Claims15
A process for producing a compound represented by the general formula (II):
- the process comprising reacting a compound represented by the general formula (I):
- with (R)-α-phenylethylamine using aqueous acetone or aqueous ethyl acetate as a solvent.
Dependencies are inferred from the claim text.