Crystals of hydrochloride of pyridazin-3(2h)-one compound and process for production of same
AssigneeNissan Chemical Industries, Ltd.
InventorsShiro Kawahara, Junichi Nishitani
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Abstract
Provided are novel crystals of 4-bromo-6-(3-(4-chloro-phenyl)propoxy)-5-(pyridin-3-ylmethylamino)pyridazin-3(2H)-one monohydrochloride, and a process for production of same. A-form crystals of 4-bromo-6-(3-(4-chlorophenyl)propoxy)-5-(pyridin-3-ylmethylamino)pyridazin-3(2H)-one monohydro-chloride represented by formula (1), which exhibit a powder X-ray diffraction pattern with characteristic peaks at diffraction angles (2θ) of 8.24, 11.24, 11.76, 16.48, 17.16, 17.80, 18.24, 19.80, 21.64, 22.56, 22.96, 23.68, 24.52, 25.92, 26.32, 27.12, 27.40, 28.00, 28.64, 29.28, 31.84 and 34.80°.
Claims20
An A-form crystal of 4-bromo-6-(3-(4-chlorophenyl)propoxy)-5-(pyridin-3-ylmethylamino)pyridazin-3(2H)-one mono-hydrochloride of formula (1),
- which has characteristic peaks at diffraction angles (2θ) of 8.24, 11.24, 11.76, 16.48, 17.16, 17.80, 18.24, 19.80, 21.64, 22.56, 22.96, 23.68, 24.52, 25.92, 26.32, 27.12, 27.40, 28.00, 28.64, 29.28, 31.84 and 34.80° in its powder X-ray diffraction pattern.
A B-form crystal of 4-bromo-6-(3-(4-chlorophenyl)propoxy)-5-(pyridin-3-ylmethylamino)pyridazin-3(2H)-one mono-hydrochloride of formula (1),
- which has characteristic peaks at diffraction angles (2θ) of 11.28, 13.28, 15.84, 16.96, 19.32, 20.60, 21.32, 23.00, 24.16, 25.96, 27.72, 28.64 and 31.12° in its powder X-ray diffraction pattern.
An H-form crystal of 4-bromo-6-(3-(4-chlorophenyl)propoxy)-5-(pyridin-3-ylmethylamino)pyridazin-3(2H)-one mono-hydrochloride of formula (1),
- which has characteristic peaks at diffraction angles (2θ) of 10.76, 11.32, 13.16, 16.16, 17.08, 18.76, 19.36, 23.00, 24.32, 26.00, 27.76 and 28.68° in its powder X-ray diffraction pattern.
Dependencies are inferred from the claim text.