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AssigneesTerumo Kabushiki Kaisha, Osaka University
InventorsMitsuru Akashi, Michiya Matsusaki, Dongjian Shi, Makoto Onishi, Yotaro Fujita
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A hydrophilic material having a hydrophilic nature and being biocompatible and processable into nanoparticles wherein a hydrophilic monomer such as threitol or a hydrophilic polymer such as polyethylene glycol is attached to the βposition of an α, β-unsaturated carboxyl group of a (co)polymer comprising an aromatic compound such as 4-hydroxycinnamic acid in which an aromatic ring is substituted by the α, β-unsaturated carboxyl group and one or more hydroxyl groups. In particular, a hydrophilic material having a nanoparticle size which is highly dispersible in water, can well migrate into the blood and is useful as a drug carrier, a medical material and a sustained drug release material.
A hydrophilic material, comprising a polymer containing an aromatic compound whose aromatic ring is substituted with an α, β-unsaturated carboxy group and one or more hydroxy groups, wherein a hydrophilic monomer or a hydrophilic polymer is attached to the β position of the α, β-unsaturated carboxy group.
Dependencies are inferred from the claim text.